PGC-1[alpha], a new therapeutic target in Huntington's disease?
Article Abstract:
Three new studies have implicated the peroxisome proliferator-activated receptor-[gamma] coactivator 1 [alpha] (PGC-1[alpha]) as an important mediator in protecting neurons against oxidative damage and its loss of function might contribute to the neurodegenerative disorder Huntington's disease (HD). The finding that PGC-1[alpha] expression is impaired in the striatum of HD patients has raised the possibility that molecules that activate PGC-1[alpha] might be therapeutically useful.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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When it comes to decisions, myeloid progenitors crave positive feedback
Article Abstract:
A study was conducted to provide evidence for a model in which positive feedback between two mutual repressors regulates the differentiation of common myeloid progenitors (CMPs) into macrophages or neutrophils. Even though positive feedback loops are diverse in both the type and number of components they contain, those that give rise to bistability tend to be nonlinear in at least one reaction.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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